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KMID : 1161420150180020173
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Journal of Medicinal Food
2015 Volume.18 No. 2 p.173 ~ p.181
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Dietary Lutein Modulates Growth and Survival Genes in Prostate Cancer Cells
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Rafi Mohamed M.
Kanakasabai Saravanan
Gokarn Sarita V.
Krueger Eric G.
Bright John J.
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Abstract
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Lutein is a carotenoid pigment present in fruits and vegetables that has anti-inflammatory and antitumor properties. In this study, we examined the effect of lutein on proliferation and survival-associated genes in prostate cancer (PC-3) cells. We found that in vitro culture of PC-3 cells with lutein induced mild decrease in proliferation that improved in combination treatment with peroxisome proliferator-activated receptor gamma (PPARγ) agonists and other chemotherapeutic agents. Flow cytometry analyses showed that lutein improved drug-induced cell cycle arrest and apoptosis in prostate cancer. Gene array and quantitative reverse transcription-polymerase chain reaction analyses showed that lutein altered the expression of growth and apoptosis-associated biomarker genes in PC-3 cells. These findings highlight that lutein modulates the expression of growth and survival-associated genes in prostate cancer cells.
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KEYWORD
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cancer prevention, carotenoids, lutein, PC-3 cells, prostate cancer
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